Human Embryo Research

HFEA Project R-0193 • Filming of human implantation in vitro

This information page outlines the HFEA approved research with human embryos carried out within the Magdalena Zernicka-Goetz lab in the Department of Physiology, Development and Neuroscience at the University of Cambridge. It is intended for IVF patients who may be interested in donating to our research programs. We currently receive donations from CARE Fertility, Bourn Hall Fertility Clinic, Herts & Essex Fertility Centre and King’s Fertility. The Patient Information Sheet provided to you by your clinic will have more detailed and specific information on donating embryos to research and to the projects carried out at the University of Cambridge. Please ask your IVF specialist for a copy of the Patient Information Sheet.

CARE fertility

Bourn Hall Fertility Clinic

Herts & Essex Fertility Centre

King’s Fertility

All research has been approved by the Cambridge Human Biology Research Ethics Committee and the UK Human Fertilisation and Embryology Authority (HFEA).

View information on the group conducting this research

Download the Patient Information Sheet

Funding

Current funding for this project comes from The Wellcome Trust.

Group Publications Including Human Embryo Research

Molè MA, Weberling A, Fässler R, Campbell A, Fishel S, Zernicka-Goetz M. Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Reports. 2021.

Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT Jr, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications. 2020.

Molè MA, Weberling A, Zernicka-Goetz M. Comparative analysis of human and mouse development: From zygote to pre-gastrulation. Current Topics In Developmental Biology. 2019.

Shahbazi MN, Zernicka-Goetz M. Deconstructing and reconstructing the mouse and human early embryo. Nature Cell Biology. 2018.

Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni JC, Zernicka-Goetz M. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature. 2017.

Shahbazi MN, Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty NNM, Campbell A, Devito L, Ilic D, Khalaf Y, Niakan KK, Fishel S, Zernicka-Goetz M. Self-organization of the human embryo in the absence of maternal tissues. Nature Cell Biology. 2016.

Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH. Self-organization of the in vitro attached human embryo. Nature. 2016.

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