2024

Temporal BMP4 effects on mouse embryonic and extraembryonic development

Hadas R, Rubinstein H, Mittnenzweig M, Mayshar Y, Ben-Yair R, Cheng S, Aguilera-Castrejon A, Reines N, Orenbuch AH, Lifshitz A, Chen DY

Nature. DOI:

Assembly of a stem cell-derived human postimplantation embryo model

Gantner CW, Weatherbee BA, Wang Y, Zernicka-Goetz M.

Nature Protocols. DOI:

Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.

Zhu M, Meglicki M, Lamba A, Wang P, Royer C, Turner K, Jauhar MA, Jones C, Child T, Coward K, Na J, Zernicka-Goetz M

Nat Struct Mol Bio. DOI: 10.1038/s41594-024-01311-9

The first two blastomeres contribute unequally to the human embryo.

Junyent S, Meglicki M, Vetter R, Mandelbaum R, King C, Patel EM, Iwamoto-Stohl L, Reynell C, Chen DY, Rubino P, Arrach N, Paulson RJ, Iber D, Zernicka-Goetz M

Cell. DOI: 10.1016/j.cell.2024.04.029

Distinct pathways drive anterior hypoblast specification in the implanting human embryo

Weatherbee BA, Weberling A, Gantner CW, Iwamoto-Stohl LK, Barnikel Z, Barrie A, Campbell A, Cunningham P, Drezet C, Efstathiou P, Fishel S

Nature Cell Biology. DOI: 10.1038/s41556-024-01367-1

2023

Assembly of complete mouse embryo models from embryonic and induced stem cell types in vitro.

Lau KYC, Amadei G, Zernicka-Goetz M.

Nat Protoc.. DOI: 10.1038/s41596-023-00891-y

Topical section: embryonic models (2023) for Current Opinion in Genetics & Development

Handford CE, Junyent S, Jorgensen V, Zernicka-Goetz M.

Curr Opin Genet Dev.. DOI: 10.1016/j.gde.2023.102134

A model of the post-implantation human embryo derived from pluripotent stem cells

Weatherbee BAT, Gantner CW, Iwamoto-Stohl L K, Daza RM, Hamazaki N, Shendure J, Zernicka-Goetz M

Nature. DOI: 10.1038/s41586-023-06368-y

Generation of Stem Cell-Based Mouse Embryo-Like Structures.

Handford CE, Panda P, Mohammad Choudhury IB, Amadei G, Zernicka-Goetz M.

Methods Mol Biol.. DOI: 10.1007/7651_2023_493

Progress and challenges in stem cell biology.

Apostolou E, Blau H, Chien K, Lancaster MA, Tata PR, Trompouki E, Watt FM, Zeng YA, Zernicka-Goetz M.

Nat Cell Biol.. DOI: 10.1038/s41556-023-01087-y

2022

Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension

Bao M, Cornwall-Scoones J, Sanchez-Vasquez E, Chen DY, De Jonghe J, Shadkhoo S, Hollfelder F, Thomson M, Glover DM & Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/s41556-022-00984-y

Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development

Lau KYC, Rubinstein H, Gantner CW, Hadas R, Amadei G, Stelzer Y, Zernicka-Goetz M

Cell Stem Cell. DOI: https://doi.org/10.1016/j.stem.2022.08.013

Synthetic embryos complete gastrulation to neurulation and organogenesis

Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz M, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M.

Nature. DOI: https://doi.org/10.1038/s41586-022-05246-3

Stain-free detection of embryo polarization using deep learning

Cheng Shen, Adiyant Lamba, Meng Zhu, Ray Zhang, Magdalena Zernicka-Goetz, and Changhuei Yang

Sci Rep. DOI: 10.1038/s41598-022-05990-6

2021

Human embryo polarization requires PLC signaling to mediate trophectoderm specification

Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, Mandelbaum RS, Paulson RJ, Mole MA, Esbert M, Titus S, Scott RT, Campbell A, Fishel S, Gradinaru V, Zhao H, Wu K, Chen ZJ, Seli E, de Los Santos MJ, Zernicka Goetz M

eLife. DOI: 10.7554/eLife.65068

Reconstructing aspects of human embryogenesis with pluripotent stem cells

Sozen B, Jorgensen V, Weatherbee BAT, Chen S, Zhu M, Zernicka-Goetz M.

Nat Commun. DOI: 10.1038/s41467-021-25853-4

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

Rawlings TM, Makwana K, Taylor DM, Molè MA, Fishwick KJ, Tryfonos M, Odendaal J, Hawkes A, Zernicka-Goetz M, Hartshorne GM, Brosens JJ, Lucas ES

eLife. DOI: 10.7554/eLife.69603

An in vitro stem cell model of humen epiblast and yolk sac interaction

Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford1,4, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi and Zernicka-Goetz M.

eLife. DOI: 10.7554/eLife.63930

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Molè MA, Coorens THH, Shahbazi MN, Weberling A, Weatherbee BAT, Gantner CW, Sancho-Serra C, Richardson L, Drinkwater A, Syed N, Engley S, Snell P, Christie L, Elder K, Campbell A, Fishel S, Behjati S, Vento-Tormo R, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-021-23758-w

The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking

Sozen B, Cornwall-Scoones J, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2020.12.005

Modeling human embryo development with embryonic and extra-embryonic stem cells

Weatherbee BAT, Cui T, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2020.12.010

Unifying synthetic embryology

Cornwall-Scoones J, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2021.03.007

Embryo size regulates the timing and mechanism of pluripotent tissue morphogenesis

Orietti LC, Rosa VS, Antonica F, Kyprianou C, Mansfield W, Marques-Souza H, Shahbazi MN, Zernicka-Goetz M

Stem Cell Reports. DOI: 10.1016/j.stemcr.2020.09.004

Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro

Guo J, Wang P, Sozen B, Qiu H, Zhu Y, Zhang X, Ming J, Zernicka-Goetz M, Na J

Stem Cell Reports. DOI: 10.1016/j.stemcr.2021.03.018

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q

Nature Cell Biology. DOI: 10.1038/s41556-021-00652-7

Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

Molè MA, Weberling A, Fässler R, Campbell A, Fishel S, Zernicka-Goetz M

Cell Reports. DOI: 10.1016/j.celrep.2021.108834

Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro

Amadei G, Lau KYC, De Jonghe J, Gantner CW, Sozen B, Chan C, Zhu M, Kyprianou C, Hollfelder F, Zernicka-Goetz M

Developmental Cell. DOI: 10.1016/j.devcel.2020.12.004

BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo

Sozen B, Demir N, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2020.11.005

Trophectoderm mechanics direct epiblast shape upon embryo implantation

Weberling A, Zernicka-Goetz M

Cell Reports. DOI: 10.1016/j.celrep.2020.108655

2020

Developmental clock and mechanism of de novo polarization of the mouse embryo

Zhu M, Cornwall-Scoones J, Wang P, Handford CE, Na J, Thomson M, Zernicka-Goetz M

Science (New York, N.y.). DOI: 10.1126/science.abd2703

Principles of Self-Organization of the Mammalian Embryo

Zhu M, Zernicka-Goetz M

Cell. DOI: 10.1016/j.cell.2020.11.003

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M

Nature Cell Biology. DOI: 10.1038/s41556-020-0573-1

Starting life in space

Cornwall-Scoones J, Zernicka-Goetz M

National Science Review. DOI: 10.1093/nsr/nwaa102

Developmental potential of aneuploid human embryos cultured beyond implantation

Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT Jr, Seli E, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-020-17764-7

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester

Weatherbee BAT, Glover DM, Zernicka-Goetz M

Open Biology. DOI: 10.1098/rsob.200162

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

Singla S, Iwamoto-Stohl LK, Zhu M, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-020-16796-3

Basement membrane remodelling regulates mouse embryogenesis

Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I, Zernicka-Goetz M

Nature. DOI: 10.1038/s41586-020-2264-2

Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo

Zhu M, Zernicka-Goetz M

Developmental Cell. DOI: 10.1016/j.devcel.2020.03.012

Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives

Zhu M, Zernicka-Goetz M

Current Opinion In Cell Biology. DOI: 10.1016/j.ceb.2019.11.005

2019

Comparative analysis of human and mouse development: From zygote to pre-gastrulation

Molè MA, Weberling A, Zernicka-Goetz M

Current Topics In Developmental Biology. DOI: 10.1016/bs.ctdb.2019.10.002

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

Sozen B, Cox AL, De Jonghe J, Bao M, Hollfelder F, Glover DM, Zernicka-Goetz M

Developmental Cell. DOI: 10.1016/j.devcel.2019.11.014

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M

Nature Cell Biology. DOI: 10.1038/s41556-019-0402-6

Voices in methods development

Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X

Nature Methods. DOI: 10.1038/s41592-019-0585-6

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Christodoulou N, Weberling A, Strathdee D, Anderson KI, Timpson P, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-019-11482-5

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

Antonica F, Orietti LC, Mort RL, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2019.03.016

Self-organization of stem cells into embryos: A window on early mammalian development

Shahbazi MN, Siggia ED, Zernicka-Goetz M

Science (New York, N.y.). DOI: 10.1126/science.aax0164

2018

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development

Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M

Cell. DOI: 10.1016/j.cell.2018.11.027

Debate ethics of embryo models from stem cells

Rivron N, Pera M, Rossant J, Martinez Arias A, Zernicka-Goetz M, Fu J, van den Brink S, Bredenoord A, Dondorp W, de Wert G, Hyun I, Munsie M, Isasi R

Nature. DOI: 10.1038/d41586-018-07663-9

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N, Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/s41556-018-0211-3

Deconstructing and reconstructing the mouse and human early embryo

Shahbazi MN, Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/s41556-018-0144-x

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Sozen B, Amadei G, Cox A, Wang R, Na E, Czukiewska S, Chappell L, Voet T, Michel G, Jing N, Glover DM, Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/s41556-018-0147-7

In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells

Harrison SE, Sozen B, Zernicka-Goetz M

Nature Protocols. DOI: 10.1038/s41596-018-0005-x

Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

Chen Q, Shi J, Tao Y, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-018-04155-2

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, Vlahov N, Grawenda A, Haider S, Chauhan J, Buti L, Kanapin A, Lu X, Buffa F, Dianov G, von Kriegsheim A, Matallanas D, Samsonova A, Zernicka-Goetz M, O'Neill E

Nature Communications. DOI: 10.1038/s41467-017-02786-5

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis

Strauss B, Harrison A, Coelho PA, Yata K, Zernicka-Goetz M, Pines J

The Journal Of Cell Biology. DOI: 10.1083/jcb.201612147

2017

Delivery of mtZFNs into Early Mouse Embryos

McCann BJ, Cox A, Gammage PA, Stewart JB, Zernicka-Goetz M, Minczuk M

Methods In Molecular Biology (Clifton, N.j.). DOI: 10.1007/978-1-4939-8799-3_16

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Shahbazi MN, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito LG, Noli L, Macaulay IC, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni JC, Zernicka-Goetz M

Nature. DOI: 10.1038/nature24675

Revisiting the Warnock rule

Hurlbut JB, Hyun I, Levine AD, Lovell-Badge R, Lunshof JE, Matthews KRW, Mills P, Murdoch A, Pera MF, Scott CT, Tizzard J, Warnock M, Zernicka-Goetz M, Zhou Q, Zoloth L

Nature Biotechnology. DOI: 10.1038/nbt.4015

Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes

Bury L, Coelho PA, Simeone A, Ferries S, Eyers CE, Eyers PA, Zernicka-Goetz M, Glover DM

The Journal Of Cell Biology. DOI: 10.1083/jcb.201606077

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

Zhu M, Leung CY, Shahbazi MN, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/s41467-017-00977-8

Delayed APC/C activation extends the first mitosis of mouse embryos

Ajduk A, Strauss B, Pines J, Zernicka-Goetz M

Scientific Reports. DOI: 10.1038/s41598-017-09526-1

The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo

Goolam M, Zernicka-Goetz M

Development (Cambridge, England). DOI: 10.1242/dev.144139

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

Harrison SE, Sozen B, Christodoulou N, Kyprianou C, Zernicka-Goetz M

Science (New York, N.y.). DOI: 10.1126/science.aal1810

An interview with Magdalena Zernicka-Goetz

Yan W

Biology Of Reproduction. DOI: 10.1093/biolre/iox003

2016

Polarity and cell division orientation in the cleavage embryo: from worm to human

Ajduk A, Zernicka-Goetz M

Molecular Human Reproduction. DOI: 10.1093/molehr/gav068

Investigations at the 'Four-Front' of Mammalian Development

Ralston A

Trends In Genetics : Tig. DOI: 10.1016/j.tig.2016.05.005

Self-organization of the human embryo in the absence of maternal tissues

Shahbazi MN, Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty NNM, Campbell A, Devito L, Ilic D, Khalaf Y, Niakan KK, Fishel S, Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/ncb3347

Self-organization of the in vitro attached human embryo

Deglincerti A, Croft GF, Pietila LN, Zernicka-Goetz M, Siggia ED, Brivanlou AH

Nature. DOI: 10.1038/nature17948

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo

Panamarova M, Cox A, Wicher KB, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M

Development (Cambridge, England). DOI: 10.1242/dev.131961

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Bolton H, Graham SJL, Van der Aa N, Kumar P, Theunis K, Fernandez Gallardo E, Voet T, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/ncomms11165

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

Goolam M, Scialdone A, Graham SJL, Macaulay IC, Jedrusik A, Hupalowska A, Voet T, Marioni JC, Zernicka-Goetz M

Cell. DOI: 10.1016/j.cell.2016.01.047

2015

Polarity in Cell-Fate Acquisition in the Early Mouse Embryo

Leung CY, Zhu M, Zernicka-Goetz M

Current Topics In Developmental Biology. DOI: 10.1016/bs.ctdb.2016.04.008

Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo

Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K, Zernicka-Goetz M

Cell Research. DOI: 10.1038/cr.2015.104

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM

Open Biology. DOI: 10.1098/rsob.150209

Mapping the journey from totipotency to lineage specification in the mouse embryo

Leung CY, Zernicka-Goetz M

Current Opinion In Genetics & Development. DOI: 10.1016/j.gde.2015.08.002

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes

Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX, Teng MJ, Goolam M, Saurat N, Coupland P, Shirley LM, Smith M, Van der Aa N, Banerjee R, Ellis PD, Quail MA, Swerdlow HP, Zernicka-Goetz M, Livesey FJ, Ponting CP, Voet T

Nature Methods. DOI: 10.1038/nmeth.3370

Cell death and morphogenesis during early mouse development: are they interconnected?

Bedzhov I, Zernicka-Goetz M

Bioessays : News And Reviews In Molecular, Cellular And Developmental Biology. DOI: 10.1002/bies.201400147

Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition

Jedrusik A, Cox A, Wicher KB, Glover DM, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2014.12.004

2014

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

Graham SJ, Wicher KB, Jedrusik A, Guo G, Herath W, Robson P, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/ncomms6667

From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo

Zernicka-Goetz M, Hadjantonakis AK

Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. DOI: 10.1098/rstb.2013.0535

Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo

Bedzhov I, Graham SJ, Leung CY, Zernicka-Goetz M

Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. DOI: 10.1098/rstb.2013.0538

In vitro culture of mouse blastocysts beyond the implantation stages

Bedzhov I, Leung CY, Bialecka M, Zernicka-Goetz M

Nature Protocols. DOI: 10.1038/nprot.2014.186

The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo

Ajduk A, Biswas Shivhare S, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2014.05.009

Citrullination regulates pluripotency and histone H1 binding to chromatin

Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T

Nature. DOI: 10.1038/nature12942

Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation

Bedzhov I, Zernicka-Goetz M

Cell. DOI: 10.1016/j.cell.2014.01.023

2013

Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles

Coelho PA, Bury L, Sharif B, Riparbelli MG, Fu J, Callaini G, Glover DM, Zernicka-Goetz M

Developmental Cell. DOI: 10.1016/j.devcel.2013.09.029

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos

Morris SA, Graham SJ, Jedrusik A, Zernicka-Goetz M

Open Biology. DOI: 10.1098/rsob.130104

Quality control of embryo development

Ajduk A, Zernicka-Goetz M

Molecular Aspects Of Medicine. DOI: 10.1016/j.mam.2013.03.001

Introduction to the special issue "Molecular Players in Early Pregnancy"

Duan EK, Wang H, Zernicka-Goetz M

Molecular Aspects Of Medicine. DOI: 10.1016/S0098-2997(13)00054-X

Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development

Skamagki M, Wicher KB, Jedrusik A, Ganguly S, Zernicka-Goetz M

Cell Reports. DOI: 10.1016/j.celrep.2013.01.006

Development: do mouse embryos play dice?

Zernicka-Goetz M

Current Biology : Cb. DOI: 10.1016/j.cub.2012.10.032

2012

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

Leung CY, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/ncomms3251

Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency

Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC

Journal Of Cell Science. DOI: 10.1242/jcs.113019

Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways

Morris SA, Guo Y, Zernicka-Goetz M

Cell Reports. DOI: 10.1016/j.celrep.2012.08.029

Protein arginine methyltransferase 6 regulates embryonic stem cell identity

Lee YH, Ma H, Tan TZ, Ng SS, Soong R, Mori S, Fu XY, Zernicka-Goetz M, Wu Q

Stem Cells And Development. DOI: 10.1089/scd.2011.0330

Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection

Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A, Graham C

Fertility And Sterility. DOI: 10.1016/j.fertnstert.2011.12.013

Dynamics of anterior-posterior axis formation in the developing mouse embryo

Morris SA, Grewal S, Barrios F, Patankar SN, Strauss B, Buttery L, Alexander M, Shakesheff KM, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/ncomms1671

2011

Advances in embryo selection methods

Ajduk A, Zernicka-Goetz M

F1000 Biology Reports. DOI: 10.3410/B4-11

Formation of distinct cell types in the mouse blastocyst

Morris SA, Zernicka-Goetz M

Results And Problems In Cell Differentiation. DOI: 10.1007/978-3-642-30406-4_11

Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability

Ajduk A, Ilozue T, Windsor S, Yu Y, Seres KB, Bomphrey RJ, Tom BD, Swann K, Thomas A, Graham C, Zernicka-Goetz M

Nature Communications. DOI: 10.1038/ncomms1424

Proclaiming fate in the early mouse embryo

Zernicka-Goetz M

Nature Cell Biology. DOI: 10.1038/ncb0211-112

2010

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes

Sharif B, Na J, Lykke-Hartmann K, McLaughlin SH, Laue E, Glover DM, Zernicka-Goetz M

Journal Of Cell Science. DOI: 10.1242/jcs.067447

Stochasticity versus determinism in development: a false dichotomy?

Zernicka-Goetz M, Huang S

Nature Reviews. Genetics. DOI: 10.1038/nrg2886

Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate

Bruce AW, Zernicka-Goetz M

Current Opinion In Genetics & Development. DOI: 10.1016/j.gde.2010.05.006

Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo

Jedrusik A, Bruce AW, Tan MH, Leong DE, Skamagki M, Yao M, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2010.04.017

Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo

Parfitt DE, Zernicka-Goetz M

Molecular Biology Of The Cell. DOI: 10.1091/mbc.E10-01-0053

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

Morris SA, Teo RT, Li H, Robson P, Glover DM, Zernicka-Goetz M

Proceedings Of The National Academy Of Sciences Of The United States Of America. DOI: 10.1073/pnas.0915063107

2009

CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation

Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, Glover DM, Zernicka-Goetz M

Stem Cells (Dayton, Ohio). DOI: 10.1002/stem.131

Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst

Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2009.04.036

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo

Zernicka-Goetz M, Morris SA, Bruce AW

Nature Reviews. Genetics. DOI: 10.1038/nrg2564

2008

Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition

Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das P, Miska E, Zernicka-Goetz M

Molecular Biology Of The Cell. DOI: 10.1091/mbc.e08-02-0219

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P, Zernicka-Goetz M

Genes & Development. DOI: 10.1101/gad.486108

Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo

Soares ML, Torres-Padilla ME, Zernicka-Goetz M

Development, Growth & Differentiation. DOI: 10.1111/j.1440-169X.2008.01059.x

Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions

Bischoff M, Parfitt DE, Zernicka-Goetz M

Development (Cambridge, England). DOI: 10.1242/dev.014316

2007

Pluripotency and differentiation in embryos and stem cells

Adjaye JA, Byskov AG, Cibelli JB, De Maria R, Minger S, Sampaolesi M, Testa G, Verfaillie C, Zernicka-Goetz M, Schöler H, Boiani M, Crosetto N, Redi CA

The International Journal Of Developmental Biology. DOI: 10.1387/ijdb.082695ja

The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation

Torres-Padilla ME, Richardson L, Kolasinska P, Meilhac SM, Luetke-Eversloh MV, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2007.06.020

Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder

Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M

Bmc Developmental Biology. DOI: 10.1186/1471-213X-7-96

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation

Frankenberg S, Smith L, Greenfield A, Zernicka-Goetz M

Bmc Developmental Biology. DOI: 10.1186/1471-213X-7-8

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling

Na J, Lykke-Andersen K, Torres Padilla ME, Zernicka-Goetz M

Developmental Biology. DOI: 10.1016/j.ydbio.2006.08.036

Histone arginine methylation regulates pluripotency in the early mouse embryo

Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M

Nature. DOI: 10.1038/nature05458

2006

The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice

Zernicka-Goetz M

Current Opinion In Genetics & Development. DOI: 10.1016/j.gde.2006.06.011

Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote

Torres-Padilla ME, Zernicka-Goetz M

The Journal Of Cell Biology. DOI: 10.1083/jcb.200603146

Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function

Na J, Zernicka-Goetz M

Current Biology : Cb. DOI: 10.1016/j.cub.2006.05.023

Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo

Richardson L, Torres-Padilla ME, Zernicka-Goetz M

Mechanisms Of Development. DOI: 10.1016/j.mod.2006.01.004

2005

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos

Torres-Padilla ME, Bannister AJ, Hurd PJ, Kouzarides T, Zernicka-Goetz M

The International Journal Of Developmental Biology. DOI: 10.1387/ijdb.052073mt

Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005)

Hiiragi T, Alarcon VB, Fujimori T, Louvet-Vallee S, Maleszewski M, Marikawa Y, Maro B, Solter D

The International Journal Of Developmental Biology. DOI: 10.1387/ijdb.062181th

Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi

Soares ML, Haraguchi S, Torres-Padilla ME, Kalmar T, Carpenter L, Bell G, Morrison A, Ring CJ, Clarke NJ, Glover DM, Zernicka-Goetz M

Bmc Developmental Biology. DOI: 10.1186/1471-213X-5-28

Cleavage pattern and emerging asymmetry of the mouse embryo

Zernicka-Goetz M

Nature Reviews. Molecular Cell Biology. DOI: 10.1038/nrm1782

PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles

Moore CA, Zernicka-Goetz M

Reproduction (Cambridge, England). DOI: 10.1530/rep.1.00651

Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo

Piotrowska-Nitsche K, Zernicka-Goetz M

Mechanisms Of Development. DOI: 10.1016/j.mod.2004.11.014

The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation

Mesnard D, Filipe M, Belo JA, Zernicka-Goetz M

Current Biology : Cb. DOI: 10.1016/j.cub.2004.01.026

A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo

Wang QT, Piotrowska K, Ciemerych MA, Milenkovic L, Scott MP, Davis RW, Zernicka-Goetz M

Developmental Cell. DOI: 10.1016/s1534-5807(03)00404-0

2003

RNA interference by production of short hairpin dsRNA in ES cells, their differentiated derivatives, and in somatic cell lines

Grabarek JB, Wianny F, Plusa B, Zernicka-Goetz M, Glover DM

Biotechniques. DOI: 10.2144/03344st02

Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro

Durcova-Hills G, Wianny F, Merriman J, Zernicka-Goetz M, McLaren A

Differentiation; Research In Biological Diversity. DOI: 10.1046/j.1432-0436.2003.710204.x

Determining the first cleavage of the mouse zygote

Zernicka-Goetz M

Reproductive Biomedicine Online. DOI: 10.1016/s1472-6483(10)61704-x

2000

Animal and vegetal poles of the mouse egg predict the polarity of the embryonic axis, yet are nonessential for development

Ciemerych MA, Mesnard D, Zernicka-Goetz M

Development (Cambridge, England). DOI: 10.1242/dev.127.16.3467

1991–1998

Fertile offspring derived from mammalian eggs lacking either animal or vegetal poles

Zernicka-Goetz M

Development (Cambridge, England). DOI: 10.1242/dev.125.23.4803

Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation

Wianny F, Tavares A, Evans MJ, Glover DM, Zernicka-Goetz M

Chromosoma. DOI: 10.1007/s004120050327

Following cell fate in the living mouse embryo

Zernicka-Goetz M, Pines J, McLean Hunter S, Dixon JP, Siemering KR, Haseloff J, Evans MJ

Development (Cambridge, England). DOI: 10.1242/dev.124.6.1133

Protein phosphatases control MAP kinase activation and microtubule organization during rat oocyte maturation

Zernicka-Goetz M, Verlhac MH, Géraud G, Kubiak JZ

European Journal Of Cell Biology. DOI:

An indelible lineage marker for Xenopus using a mutated green fluorescent protein

Zernicka-Goetz M, Pines J, Ryan K, Siemering KR, Haseloff J, Evans MJ, Gurdon JB

Development (Cambridge, England). DOI: 10.1242/dev.122.12.3719

Cytostatic factor inactivation is induced by a calcium-dependent mechanism present until the second cell cycle in fertilized but not in parthenogenetically activated mouse eggs

Zernicka-Goetz M, Ciemerych MA, Kubiak JZ, Tarkowski AK, Maro B

Journal Of Cell Science. DOI: 10.1242/jcs.108.2.469

Activation of embryonic genes during preimplantation rat development

Zernicka-Goetz M

Molecular Reproduction And Development. DOI: 10.1002/mrd.1080380106

Okadaic acid affects spindle organization in metaphase II-arrested rat oocytes

Zernicka-Goetz M, Maro B

Experimental Cell Research. DOI: 10.1006/excr.1993.1179

Cytoskeletal organization of rat oocytes during metaphase II arrest and following abortive activation: a study by confocal laser scanning microscopy

Zernicka-Goetz M, Kubiak JZ, Antony C, Maro B

Molecular Reproduction And Development. DOI: 10.1002/mrd.1080350210

Full activation of the rat oocyte by protein synthesis inhibition requires protein phosphatase activity

Zernicka-Goetz M, Weber M, Maro B

The International Journal Of Developmental Biology. DOI:

Spontaneous and induced activation of rat oocytes

Zernicka-Goetz M

Molecular Reproduction And Development. DOI: 10.1002/mrd.1080280210